Labstract Ltd

Bioscience training courses

TRAINING COURSES

Our chemistry & biology labs are ideally suited for practical training courses giving participants hands-on experience across a range of modern techniques.

 

The training courses are part-funded by ideaSpace to enhance skills across a wide range of business areas.

 

Labstract’s courses are specifically targeted at scientists who are in the early stages of their career in medicinal chemistry, and also graduates, PhDs and post-docs considering a career involving practical medicinal chemistry.

 

We also work in partnership with technology providers to deliver training on instrumentation for confocal microscopy, cell imaging, capillary electrophoresis.

 

Find out about new courses from Labstract by joining our mailing list.

 

Previous training courses include:

 

An Introduction to Flow Cytometry

This one day course is for complete beginners or those interested in learning more about both the theoretical and practical aspects of flow cytometry.

 

The day is split into a number of short talks, including; an introduction to fluorescence and fluorochromes, the basics of flow cytometry, data analysis, fluorescence compensation, experimental design, statistics, data presentation and applications. The course ends with a demonstration of a flow cytometer in Labstract's laboratory. 

 

Derek Davies, who currently runs the Flow Cytometry Laboratory at the London Research Institute will lead this course. 

 

ADME Workshop

The course gives an overview of the ADME process and covers concepts such as solubility, permeability, Pgp, CYP 450’s, Phase 1 & 2 metabolism, glomerular filtration and enteropathic cycling. The course demystifies pharmacokinetic terms such as t1/2, clearance and volume of distribution. An interactive workshop will give participants insight into the importance of the routes of administration.

 

The course places heavy emphasis on the use of current medicinal chemistry literature to solve recurrent ADME issues. Using the ‘succeed through the literature approach’ participants will distil out working solutions to issues such as solubility, oral absorption, CNS penetration and duration of action.

 

The workshop is suited to people in academia that have an interest in current issues in the drug discovery process. It is particularly recommended to medicinal chemists who have recently joined the pharmaceutical industry and more experienced medicinal chemists who wish to pull together a range of notions they have picked up in the course of their projects.

 

Course delivered by Corinne Kay, Director, Med-Simple.

 

Practical medicinal chemistry

An introduction to techniques used in a modern industrial medicinal chemistry laboratory. The course is delivered by Dr Suki Klair who has 15 years’ experience as a medicinal chemist working for CRO’s, small biotechs and large pharmaceutical companies, synthesising compounds for medicinal chemistry programmes in oncology and GPCRs.

 

The course starts with a general introduction to laboratory safety, good lab notebook keeping and simplifying mathematical calculations for chemists. The course then progresses to methods for measuring solids, liquids and gases, reaction set-up, reaction monitoring, product isolation & purification and tools for product analysis. The course concludes with an insight into tools and techniques used in parallel synthesis.

 

NMR for medicinal chemists

This one-day course starts by covering the basic elements of 1-dimensional NMR techniques in medicinal chemistry including chemical shift, J-couplings between nuclei, structural information from coupling constants, second order effects, intensity & integration. All topics are presented with reference to drug-like molecules and precursors. The course then moves on to cover more advanced techniques such as homo- and heteronuclear 2-dimensional experiments, through space interactions, the nOe effect and magnetic non-equivalence. The course concludes with a worked-through case study and a group problem-solving session. Practical aspects of spectroscopy including sample preparation and basic shimming techniques are also covered.

 

Practical flow chemistry

An introduction to the principles of flow chemistry. How and when to apply the technique with

pertinent illustrative examples of chemistry & equipment. Followed by a tutorial/workshop covering batch to flow conversion and troubleshooting with worked examples. Finishing with a practical demonstration session on commercial flow chemistry apparatus.

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Our courses take place at our state of the art laboratories.

 

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